3: Masher's comeuppance, maybe
4: Experience a lack of oxygen, perhaps
6: Reason and Enlightenment
10: Splashed through the pool
12: Dermatologist's concern
15: Professionals who might get under your skin?
24: Hot and cool at the same time
26: Coin of Nepal or Pakistan
44: Spanish title of respect
49: Balloon filler, maybe
50: Root beer alternative
53: Investigator's assignment
56: Grocery shopper's reference