4: Feature of Karloff's Frankenstein monster
8: Tenth letter of the Greek alphabet
19: Beloved Ralph and Alice?
25: Answering-machine sound
35: Clarence in 'It's a Wonderful Life'
43: Holmes mantra, and a hint to this puzzle's theme
49: Ones who tell you when your slip is showing?
58: Well-organized, in a sense
66: Dermatologist's concern